Sevilla are unbeaten against Manchester United (W2, D2) and their new manager, José Mendilibar, has also won two and drawn two since taking over.
Winning the Europa League may be the only route to qualification for next season’s European competition, which is why Sevilla rested some key players for their recent game against Valencia.
Meanwhile, United secured a comfortable 2-0 win against Nottingham Forest in the league.
Despite the defensive errors and own goals in the first leg, United should still expect to qualify for the semi-finals.
They have won seven of their last ten matches by a margin of 2+ and have already shown their mettle against Spanish opposition, drawing 2-2 with Barcelona before securing a 2-1 win at home.
Read below for our Europa League Tips